Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jul 25;16(4):4193–4200. doi: 10.3892/ol.2018.9217

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Moon et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Figure 6. — Proposed schematic representation of the mechanism underlying the proapoptotic effect of SCE. SCE induces ROS-dependent expression of proapoptotic proteins, including p53, p21 and Bax. These proteins induce the apoptosis of HCT116 cells through activating the intrinsic mitochondrial pathway. SCE, Sorbus commixta water extract; ROS, reactive oxygen species; Bcl-2, B-cell lymphoma-2; Bax, Bcl-2-associated X protein; NAC, N-acetyl cysteine; Mdm2, mouse double minute 2 homology; PARP, poly ADP-ribose polymerase.