. Author manuscript; available in PMC: 2018 Sep 6.

Published in final edited form as: Aging Cell. 2013 Apr 10;12(3):459–466. doi: 10.1111/acel.12068

Table 2.

Biological serum parameters in older patients, according to MPI grades

	Multidimensional I Prognostic Index					Correlations
	MPI-1 (low risk) N = 201	MPI-2 (moderate risk) N = 201	MPI-3 (severe risk) N = 192	Test for linear trend (P-value)	MPI-3 vs. MPI-1 (P-value)	Spearman's rho	P-value
White blood cells (1000 μL⁻¹)	7.27 ± 2.18	7.84 ± 3.23	9.25 ± 4.44	0.004	0.005	0.205	< 0.001
Lymphocytes (1000 μL⁻¹)	2.05 ± 0.77	1.90 ± 0.95	1.68 ± 0.69	0.031	0.035	−0.204	< 0.001
C-reactive protein (pg mL⁻¹)^*	1.97 ± 4.00	2.85 ± 4.77	5.65 ± 7.49	< 0.001	< 0.001	0.358	< 0.001
Erythrocyte sedimentation rate (mm)	30.19 ± 24.14	42.86 ± 28.73	52.28 ± 33.30	< 0.001	< 0.001	0.288	< 0.001
Iron (μg dL⁻¹)	71.64 ± 37.40	57.63 ± 33.44	49.26 ± 31.39	< 0.001	< 0.001	−0.278	< 0.001
Hemoglobin (g dL⁻¹)	12.94 ± 2.01	12.17 ± 1.92	11.97 ± 2.09	0.191	0.176	−0.233	< 0.001
Albumin (g dL⁻¹)	61.67 ± 4.52	60.48 ± 5.50	56.75 ± 7.19	< 0.001	< 0.001	−0.292	< 0.001
Glycemia (mg dL⁻¹)^†	104.33 ± 37.29	111.75 ± 50.30	118.58 ± 54.24	0.127	0.130	0.103	0.012
Triglycerides (mg dL⁻¹)^‡	123.82 ± 86.84	122.13 ± 66.22	118.92 ± 62.60	0.903	0.887	−0.012	0.769
Total cholesterol (mg dL⁻¹)^‡	177.00 ± 47.02	160.24 ± 43.23	153.86 ± 44.57	0.006	0.006	−0.225	< 0.001
HDL cholesterol (mg dL⁻¹^‡	43.47 ± 18.10	40.41 ± 13.35	37.56 ± 15.41	0.006	0.006	−0.146	< 0.001
LDL cholesterol (mg dL⁻¹)^‡	105.89 ± 35.95	98.34 ± 37.80	90.19 ± 39.01	0.012	0.014	−0.201	< 0.001
Insulin (μU mol⁻)	9.22 ± 9.38	9.33 ± 7.03	11.99 ± 36.33	0.500	0.525	−0.027	0.514
FT3 (pg mL⁻¹)^$	2.89 ± 0.65	2.79 ± 0.61	2.49 ± 0.68	< 0.001	0.001	−0.270	< 0.001
DHEA-S (μg dL⁻¹)	63.78 ± 61.98	46.58 ± 37.90	47.39 ± 39.21	0.851	0.920	−0.128	0.002
Men	85.01 ± 74.55	56.41 ± 39.93	57.42 ±51.27	0.039	0.041	−0.201	0.002
Women	46.56 ± 42.66	40.48 ± 35.38	42.38 ± 30.53	0.125	0.154	−0.035	0.504
IGF-1 (ng mL⁻¹)	87.44 ± 39.88	82.25 ± 45.37	60.56 ± 29.95	< 0.001	< 0.001	−0.305	< 0.001
Free testosterone (pg mL⁻¹)	35.85 ±38.14	23.18 ± 27.21	20.64 ± 30.47	0.050	0.036	−0.143	0.001
Men	70.13 ± 30.40	48.65 ± 24.23	50.19 ± 38.69	0.021	0.022	−0.366	< 0.001
Women	8.86 ± 14.70	7.42 ± 13.64	6.52 ± 6.76	0.769	0.795	0.001	0.985

	N (%)	N (%)	N (%)

1-month mortality (ev per pm, IR%)	2/198(1.0)	9/197 (4.6)	29/174(16.7)	< 0.001
1-year mortality (ev per py, IR%)	11/196(5.6)	35/177(19.7)	63/145 (43.5)	< 0.001

pm, person/month; py, person/year; IR%, incidence rate%.

All analyses were adjusted for age, gender, and comorbidity. Subgroup analyses were adjusted for age and comorbidity only. Analyses were

also adjusted for statins and FANS

^†

also adjusted for cortisone

^‡

also adjusted for statins

also adjusted for hormone therapy.