Fig. 1.

A, schematic diagram showing the direct integration of LCM with nanoPOTS using DMSO droplets for tissue capture. B, Image of a nanoPOTS chip with an array of 200-nL prepopulated DMSO droplets. C, Direct mounting of a nanoPOTS chip on a slide adapter for a PALM MicroBeam LCM system. D, Microdissected tissue section and E, the corresponding tissue pieces collected in nanowells with square lateral dimensions from 20 μm to 200 μm. A 12-μm-thick rat brain coronal section was used as model sample.