Table 12.

Change scores and standardized effect sizes on QOLIE-31-P scores based on the change from baseline in seizure frequency during the last 12 weeks of the core phase.

Domain	Category	Mean change	SD	Effect size	t-Test p-value
Quality of life item	Responders	7.5	10.2	0.39	0.121
	Non-responders	−2.7	16.0	−0.18
Emotional well-being	Responders	11.4	25.4	0.36	0.066
	Non-responders	−5.8	20.3	−0.43
Social function	Responders	19.1	23.6	1.19	0.088
	Non-responders	2.3	22.2	0.10
Cognitive	Responders	21.1	19.5	1.60	0.024∗
	Non-responders	1.8	19.2	0.08
Medication effects	Responders	5.2	26.2	0.24	0.301
	Non-responders	−5.9	24.3	−0.22
Seizure worry	Responders	18.3	25.7	0.65	0.019∗
	Non-responders	0.0	15.0	0.00
Energy/fatigue	Responders	6.0	23.2	0.23	0.579
	Non-responders	1.0	20.0	0.06
Total score	Responders	15.2	15.7	0.74	0.021∗
	Non-responders	−0.6	15.3	−0.03

^∗Items in this domain met significant level of p < 0.05 demonstrating a significant difference between responders vs. non-responders.