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. 2018 Aug 31;11:5371–5381. doi: 10.2147/OTT.S170775

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© 2018 Gao et al. This work is published and licensed by Dove Medical Press Limited

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STARD13 suppresses YAP translocation from nuclear to cytoplasm via inhibiting RhoA activity.

Notes: (A) The expression of p-YAP and its target CTGF were evaluated in HCC cells with STARD13 overexpression or not. (B) YAP translocation from nuclear to cytoplasm was detected in cells depicted in (A) via immunofluorescent assay. (C) The luciferase activity of 8xGTIIC-luciferase plasmid was examined in cells depicted in (A). (D) The expression of p-YAP and CTGF was measured in HCC cells with STARD13 overexpression as well as RhoA overexpression or not. (E) The luciferase activity of 8xGTIIC-luciferase plasmid was examined in cells depicted in (D). Data were presented as mean ± SD; ^*P<0.05; ^**P<0.01 vs HepG2 or Huh7.

Abbreviations: HCC, hepatocellular carcinoma; STARD13, StAR-related lipid transfer domain 13.

STARD13 suppresses YAP translocation from nuclear to cytoplasm via inhibiting RhoA activity.

Notes: (A) The expression of p-YAP and its target CTGF were evaluated in HCC cells with STARD13 overexpression or not. (B) YAP translocation from nuclear to cytoplasm was detected in cells depicted in (A) via immunofluorescent assay. (C) The luciferase activity of 8xGTIIC-luciferase plasmid was examined in cells depicted in (A). (D) The expression of p-YAP and CTGF was measured in HCC cells with STARD13 overexpression as well as RhoA overexpression or not. (E) The luciferase activity of 8xGTIIC-luciferase plasmid was examined in cells depicted in (D). Data were presented as mean ± SD; ^*P<0.05; ^**P<0.01 vs HepG2 or Huh7.

Abbreviations: HCC, hepatocellular carcinoma; STARD13, StAR-related lipid transfer domain 13.