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Proposed model for STARD13 inhibiting HCC cell stemness, enhancing drug resistance.
Notes: STARD13 acts as a potential inhibitor of YAP transcriptional activity by blocking RhoA–F-actin signaling cascade through its Rho GTPase activity. This inhibition inhibits HCC stemness, thus enhancing drug sensitivity.
Abbreviations: F-actin, filamentous actin; HCC, hepatocellular carcinoma; STARD13, StAR-related lipid transfer domain 13.
