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. Author manuscript; available in PMC: 2018 Sep 6.
Published in final edited form as: Cancer Res. 2017 Aug 14;77(19):5301–5312. doi: 10.1158/0008-5472.CAN-17-0418

Figure 1. FAK regulates SCC tumor growth, cell cycle and angiogenesis in vivo.

Figure 1

(a) Growth of SCC FAK-wt and SCC FAK-/- tumor xenografts in CD-1 nude mice. n = 5 - 6 tumors per group. (b) SCC FAK-wt and SCC FAK-/- tumor doubling time. Unpaired T-test, ****p < 0.0001. (c) Intra-vital imaging of FUCCI expressing SCC FAK-wt and SCC FAK-/- cells 24 hours post-implantation under dorsal skinfold windows. (d) Quantitation of FUCCI cell cycle distribution from 3-dimentional image stacks shown in panel c. Sidak’s corrected 2way ANOVA, ***p < 0.001. n = 4 tumors per group. (e) Longitudinal imaging of tumour angiogenesis following implantation of tumour fragments under dorsal skinfold windows. Red – tagRFP labelled SCC tumor, Green – tissue autofluorescence. (f) Quantitation of blood vessel density at day 9. Unpaired T-test, *p = 0.0306. Data in all graphs represented as mean +/- s.e.m. n = 3 tumors per group.