. Author manuscript; available in PMC: 2018 Dec 1.

Published in final edited form as: FEBS Lett. 2018 May 10;592(12):2168–2180. doi: 10.1002/1873-3468.13068

Table 1. Examples of hit compounds identified from DNA-encoded chemical libraries.

The following abbreviations were used for the protein targets: TNKS1 = tankyrase-1, IL2 = interleukin-2, NK3 = Neurokinin 3, MAPK14 = Mitogen-activated protein kinase 14, sEH = soluble epoxide hydrolase, CAIX = carbonic anhydrase IX, AGP = alpha-1-acid glycoprotein.

	K_d	Target	Ref
a)	290 nM (IC₅₀)	TNKS1	[31]
b)	2.5 μM	IL2	[30]
c)	2 nM (IC₅₀)	NK3	[49]
d)	7 nM (IC₅₀)	MAPK14	[50]
e)	2 nM	sEH	[51]
f)	2.6 nM	CAIX	[28]
g)	9.9 nM	AGP	[21]
h)	10 nM (IC₅₀)	RIP1	[52]
i)	7.9 nM (IC₅₀)	sEH	[53]