Fig. 2.

Evolution of injected lesions in a patient over time. A CR is observed at week 36 after beginning of treatment. In most lesions, a vitiligo-like depigmentation develops over time, as a consequence of a strong antimelanoma immunity that also targets healthy melanocytes, because of shared expression of melanocyte differentiation antigens. Data from the literature have shown that development of a vitiligo-like depigmentation in patients with melanoma may be associated with more favorable clinical outcome [61]