Skip to main content
. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Clin Cancer Res. 2018 Apr 24;24(15):3656–3667. doi: 10.1158/1078-0432.CCR-17-3457

Figure 1. General scheme of Small Molecule-Drug Conjugates (SMDCs) and chemical structures of CAIX-targeting SMDCs.

Figure 1

Compounds display an acetazolamide targeting ligand (AAZ; compound 1), an affinity matured version of acetazolamide (AAZ+; compound 2) or an amide (serving as negative control; compound 3). All products feature the cytotoxic payload MMAE, an Asp-Arg-Asp-Cys peptide spacer, a Valine-Citrulline (ValCit) dipeptide cleavable linker and a p-amino benzyl (PAB) self-immolative linker.