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. Author manuscript; available in PMC: 2019 Aug 15.
Published in final edited form as: Cancer Res. 2018 Jul 2;78(16):4524–4532. doi: 10.1158/0008-5472.CAN-17-0385

Figure 7.

Figure 7.

YIYA/CDK6 co-regulate glucose metabolic reprogramming. A, Graphic illustration of glucose metabolic pathway regulated by YIYA and CDK6. B, The percentage of [U-13C] glucose over unlabeled glucose in MDA-MB-231 cells with or without YIYA KO were glucose starved overnight, followed with [U-13C] glucose feedback (11 mM, 4 hr). C-F, Ratio of indicated metabolites in MDA-MB-231 cells with or without YIYA KO were glucose starved overnight, followed with [U-13C] glucose feedback (11 mM, 2 hr). G, Medium lactate production detection of MDA-MB-231 cells with or without YIYA KO. H and I, Medium glucose consumption (H) and lactate production (I) of MCF7 cells expressing indicated constructs (left) or BT474 cells harboring indicated shRNAs (right). J and K, The percentage of [U-13C] glucose over unlabeled glucose (J) or [U-13C] GBP/FBP over unlabeled GBP/FBP (% of pool) (K) in MDA-MB-231 cells harboring indicated shRNAs were glucose starved overnight, followed with [U-13C] glucose feedback (11 mM, 4 hr).