Fig. 8.
Schematic representation of the mechanism of YRSACT influence on megakaryopoiesis. YRSACT targets monocytic cells and signals through the TLR/MyD88 pathway, inducing cytokine secretion that facilitates MK expansion and platelet production. One remarkable effect of YRSACT is the induction of a unique subset of MKs that express Sca-1 and F4/80 as well as MK markers. Both of these mechanisms may represent the action of YRSACT on “MK-biased hematopoiesis” that contributes to rapid MK expansion and platelet replenishment under stress conditions.