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. 2018 Aug 14;115(35):E8246–E8255. doi: 10.1073/pnas.1802620115

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Copyright © 2018 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 8. — Chd7/Chd8 and Olig2/Sox10 bind to regulatory elements of active stage-specific genes in oligodendroglia. (A) Diagram representing a set of genes with timely controlled expression (data from ref. 35) divided in three groups: OPC genes (Ascl1 and Pdgfrα), iOL genes (Nkx2.2 and Gpr17), and mOL genes (Mbp and Omg). (B–G) Schematic representation from Genomatix genome browser of Ascl1 (B), Pdgfrα (C), Gpr17 (D), Nkx2.2 (E), Mbp (F), and Omg (G) locus integrating ChIP-seq data for main oligodendroglial TFs (Olig2 and Sox10), chromatin remodeling factors (Chd7, Chd8), and active epigenetic marks (H3K27ac and H3K4me3) in OPCs and OLs. (H) Synthesis representation of the dynamic cooperation between TFs (Sox10, Olig2) and chromatin remodelers (Chd7, Chd8) for the timely regulation of OPC- and OL-gene expression with genes not yet expressed (1), genes starting to express (2), expressed genes (3), and genes not expressed anymore (4).