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. 2018 Aug 24;14(8):e1007607. doi: 10.1371/journal.pgen.1007607

Fig 2. Manhattan plot and effect predictions of multi-region meta-analysis cis-eQTLs.

Fig 2

A,–log10(pmeta) are plotted for cis-eQTLs identified in a multi-region meta-analysis of eight brain regions from UKBEC and GTEX (Fig 1, analysis C). Top eGenes associated with these eQTLs are provided, along with the associated cis-eQTL and pmeta. Solid red line denotes threshold at which FDR = 0.05. Dashed red line denotes threshold at which p-value < pbonferroni (S4 Table). B, C, Overlap of cis-eQTLs and eGenes, respectively, between UKBEC+GTEx, UKBEC and GTEx with pmeta/ukbec/gtex < pbonferroni. D, Frequency of cis-eQTLs with respect to distance from associated eGene TSS (transcription start site) and TES (transcription end site). E, SNP effect prediction (from Ensembl Variant Effect Predictor) for 2,224 high-confidence cis-eQTLs.