Table 2.
Free, Total, and Percentage Free 25(OH)D and DBP by DBP Haplotype
| DBP Haplotype |
Frequency (%)
a |
Free 25(OH)D (pg/mL) b | Total 25(OH)D (ng/mL) b | Percentage Free 25(OH)D b | DBP (RID) (μg/mL) b | ||
|---|---|---|---|---|---|---|---|
| White (n = 860) | Black (n = 98) | Other (n = 1) | |||||
| 1s/1s | 31.9 | 1 | 0 | 5.1 ± 1.8 | 25.6 ± 10.0 | 0.021 ± 0.006 | 308.6 ± 40; n = 209 |
| 1s/2 | 29 | 1 | 100 | 5.1 ± 2.1 | 23.1 ± 8.4 | 0.023 ± 0.007 | 287.9 ± 36.2; n = 182 |
| 1s/1f | 22.4 | 27 | 0 | 5.4 ± 2.0 | 24.2 ± 9.0 | 0.023 ± 0.007 | 304.5 ± 39.7; n = 189 |
| 2/2 | 5.5 | 0 | 0 | 4.1 ± 2.0 | 17.8 ± 7.3 | 0.023 ± 0.007 | 260.4 ± 25.1; n = 24 |
| 1f/2 | 8.3 | 18 | 0 | 4.7 ± 1.8 | 19.6 ± 7.7 | 0.026 ± 0.010 | 289.3 ± 34.1; n = 73 |
| 1f/1f | 3 | 51 | 0 | 4.4 ± 1.6 | 18.2 ± 8.2 | 0.026 ± 0.008 | 300.1 ± 43.5; n = 73 |
a
Significant differences in frequencies of haplotypes between the races for all haplotypes except for Gc1s/1f were detected.
b
Statistically significant effects of DBP haplotype were detected for total, free, and percentage free 25(OH)D concentrations and DBP (ANOVA, P < 0.0001; see Fig. 2 and text for individual between-haplotype post hoc comparisons).