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. Author manuscript; available in PMC: 2019 Apr 10.
Published in final edited form as: Expert Opin Ther Targets. 2018 Apr 10;22(4):353–363. doi: 10.1080/14728222.2018.1451514

Table 3.

Molecular pathways implicated in Treg-mediated signaling in the TME

Pathway References
TGF-β/TGF- βRI/II: [96]
 LAP, GARP, active TGF-β
Adenosine/A2AR:
 A2aR [85]
 CD39, CD73 ectoenzymes [51]
 ADA [32]
 COX-2/PGE2 /EP2R [49]
Immune checkpoints:
 CTLA-4/ B7, PD-1/PD-L1, TIM- 3/Galectin-9, PVR [13,105]
 LAG-3/ MHC II, TIGIT/CD155 (PVR) [69]
Chemokine receptors:
 CCR-4, 5, 6, 10 [1,5]
 Fas/FasL [104]
 TNFR2/TNF [108,109]
GITR/GITRL [110]