Table 4.

Functional diversity of Treg^a

Limit tumor promoting inflammation (TPI) in response to gut microbes; important in CRC [111] Suppress production of MMP2, a major invasion-promoting factor, by TAMs [112] Regulate angiogenesis via NRP1 [113] Play a role in tissue repair: produce amphiregulin [77] Protect tissues from damage during infections [76] In the skin, regulate hair follicle differentiation from stem cells [79]

^aSome of the non-immunoregulatory functions ascribed to Treg are listed. CRC, colorectal cancer; MMP2, metalloproteinase 2; NRP, neuropilin 1