Skip to main content
. Author manuscript; available in PMC: 2019 Apr 10.
Published in final edited form as: Expert Opin Ther Targets. 2018 Apr 10;22(4):353–363. doi: 10.1080/14728222.2018.1451514

Table 5.

Therapeutic depletion or re-programming of human Trega

  • Anti-D25 Ab (daclizumab)

  • Ontak

  • Neutralizing TGF-β Abs

  • COX-2 pathway blockade

  • Adenosine pathway blockade

  • High dose cyclophosphamide

  • Low dose cyclophosphamide

  • Sunitinib

  • Fludarabine

  • Immune checkpoint blockade?

a

Antibodies, inhibitors or drugs that have been clinically used for reducing numbers/functions of Treg in patients with cancer (reviewed in [2])