Effects of Duloxetine on Urethral Continence Reflex and Bladder Activity in Rats with Cerebral Infarction

. Author manuscript; available in PMC: 2018 Sep 6.

Published in final edited form as: J Urol. 2015 Mar 21;194(3):842–847. doi: 10.1016/j.juro.2015.03.091

Effects of duloxetine on sneeze induced pressure changes and bladder activity in normal and CI rats

	Mean ± SE Normal		Mean ± SE Cl
	Pretreatment	Posttreatment	Pretreatment	Posttreatment
Sneeze induced pressure changes:
No. rats	12		6
A-URS (cm H₂O)	36.9 ± 4.3	48.3 ± 4.8^*	39.5 ± 8.6	36.8 ± 6.2
UBP (cm H₂O)	27.0 ± 2.4^†	32.7 ± 3.8^*	15.5 ± 1.6	15.2 ± 1.9
Pabd increase (cm H₂O)	8.6 ± 0.5	8.1 ± 0.6	8.2 ± 0.6	8.1 ± 0.8
Bladder activity:
No. rats	6		6
ICI (mins)	6.2 ± 0.7^‡	5.5 ± 0.7	3.9 ± 0.5	8.8 ± 1.2^§
VC (cm H₂O)	38.5 ± 2.8	41.1 ± 3.2	42.4 ± 2.7	45.0 ± 4.4
BP (cm H₂O)	5.7 ± 0.5	6.0 ± 0.4	6.6 ± 0.6	5.9 ± 0.3
PT (cm H₂O)	7.4 ± 0.7	7.3 ± 0.4	9.7 ± 1.2	8.7 ± 0.4

p <0.05 vs normal pretreatment.

^†

p <0.01 vs CI pretreatment.

^‡

p <0.05 vs CI pretreatment

^§

p <0.01 vs CI pretreatment.