Table 5.

Prostate cancer risk associated with sex hormone concentrations with and without mutual adjustment for other hormones^*

	No. of case patients/No. of control subjects	Unadjusted RR (95% CI)†	Mutually adjusted RR (95% CI)‡
Mutual adjustment set 1
Testosterone	2107/2937	1.00 (0.85 to 1.18)	1.03 (0.87 to 1.22)
Estradiol		0.92 (0.78 to 1.09)	0.92 (0.77 to 1.10)
Mutual adjustment set 2
Free testosterone	1977/2653	1.11 (0.93 to 1.32)	1.12 (0.94 to 1.35)
Free estradiol		0.99 (0.83 to 1.18)	0.95 (0.80 to 1.14)
Mutual adjustment set 3
Free testosterone	701/823	1.09 (0.80 to 1.48)	1.15 (0.82 to 1.62)
Free estradiol		1.10 (0.81 to 1.50)	0.98 (0.70 to 1.38)
Androstanediol glucuronide		1.17 (0.87 to 1.56)	1.19 (0.88 to 1.60)
DHT		0.84 (0.62 to 1.13)	0.79 (0.57 to 1.09)
Mutual adjustment set 4
Free testosterone	834/1203	1.09 (0.83 to 1.42)	1.09 (0.82 to 1.44)
Free estradiol		0.89 (0.69 to 1.16)	0.87 (0.66 to 1.13)
Androstanediol glucuronide		1.09 (0.85 to 1.41)	1.08 (0.84 to 1.41)
Androstenedione		1.11 (0.86 to 1.43)	1.08 (0.83 to 1.41)
Mutual adjustment set 5
Free testosterone	818/1187	1.11 (0.85 to 1.46)	1.15 (0.87 to 1.52)
Free estradiol		0.86 (0.66 to 1.12)	0.82 (0.63 to 1.08)
Androstanediol glucuronide		1.07 (0.83 to 1.40)	1.05 (0.81 to 1.37)
DHEA-S		1.09 (0.84 to 1.42)	1.09 (0.84 to 1.43)
Mutual adjustment set 6
SHBG	2339/3138	0.83 (0.71 to 0.97)	0.88 (0.75 to 1.04)
IGF-I		1.55 (1.32 to 1.82)	1.51 (1.29 to 1.78)

^*RR = relative risk; CI = confidence interval; DHT = dihydrotestosterone; DHEA-S = dehydroepiandrosterone sulfate; SHBG = sex hormone–binding globulin; IGF-I = insulin-like growth factor I.

^†Relative risks were from separate univariate analyses.

^‡Relative risks were from model with hormones adjusted for each other.