Table 3.
Factors identified as prognostic of disease reclassification and the derived scoring system
| Factors Prognostic of Disease Reclassification | |||
|---|---|---|---|
| Comparison values | Odds ratio | Score | |
| Caveolin-1 | <0.624 | 1.00 | 0 |
| ≥0.624 | 1.91 | 2 | |
| Age | <64 | 1.00 | 0 |
| ≥64 | 1.35 | 1 | |
| Risk group | 1 | 1.00 | 0 |
| 2 | 2.34 | 2 | |
| Tumor length | <3 | 1.00 | 0 |
| ≥3 | 1.05 | 1 | |
| Number of positive | 1 | 1.00 | 0 |
| biopsy cores | ≥1 | 1.85 | 2 |
| Scoring system | |||
| Total score | DR cases/Total (%) | Sensitivity* | Specificity* |
| 0 | 1/3 (33%) | 100% | 0% |
| 1 | 0/2 (0%) | 99% | 1% |
| 2 | 16/87 (18%) | 99% | 1% |
| 3 | 17/83 (20%) | 90% | 20% |
| 4 | 50/155 (32%) | 79% | 37% |
| 5 | 41/112 (37%) | 48% | 65% |
| 6 | 26/64 (41%) | 23% | 84% |
| 7 | 8/24 (33%) | 7% | 94% |
| 8 | 4/12 (33%) | 2% | 98% |
*
For example: Grouping patients using a total score of 4 (i.e., <4 vs. ≥4) results in a sensitivity of 79% and a specificity of 37%.