(
A) t-SNE plot from
Figure 7A showing expression of several interesting genes. Cyclin-dependent kinase inhibitor
Cdkn1a was enriched in mitotic cells, tip cells and capillary-A ECs,
Cdkn1c was enriched in artery and vein ECs.
Smad6 and
Smad7 were enriched in the capillary-A and arterial EC clusters.
Tgfb2 was widely expressed and
Ltbp4 expression was concentrated in the arterial cluster.
Cxcr4 was expressed in tip cells, capillary-A ECs, and arterial ECs.
Cxcl12 was expressed in arterial ECs. (
B) Cell trajectory analysis of genes shown in (
A).