Fig. 1.

MEDI3622 recognizes ADAM17 on mouse and human leukocytes. a Mouse peripheral blood leukocytes from control and ADAM17 conditional knockout mice (ADAM17-null) were stained with MEDI3622 or an isotype control antibody and examined by flow cytometry. y-axis = cell number. Representative data from at least three independent experiments using separate mice are shown. b Human peripheral blood leukocytes were isolated from healthy donors and stained by MEDI3622 or an isotype control antibody. Data are representative of three independent experiments using separate blood donors. c Staining by MEDI3622 was measured on CD56^bright CD3⁻ and CD56^dim CD3⁻ cells, as indicated. Isotype control antibody staining was measured on all CD56⁺ CD3⁻ cells. Bar graphs show mean fluorescence intensity (MFI) ± SD of at least three independent experiments using separate donors. ns not significant