Table 3.
Associations between cerebellar volumes, perinatal factors and neurodevelopmental outcomes in VPT children
| TEA Volume (cc) | 7-Year Volume (cc) | Growth Z-score | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||
| Perinatal Factor* | Coefficient (95% CI) | F | df | P-value | Coefficient (95% CI) | F | df | P-value | Coefficient (95% CI) | F | df | P-value |
| Sex | 0.59 (−0.30, 1.48) | 35.92 | 2,198 | 0.190 | 12.31 (7.77, 16.86) | 14.46 | 2,111 | < 0.001 | 0.99 (0.65, 1.33) | 16.98 | 2,105 | < 0.001 |
| Birth GA | 0.25 (0.01, 0.49) | 37.72 | 2,198 | 0.037 | 1.86 (0.54, 3.19) | 3.95 | 2,111 | 0.006 | 0.12 (0.02, 0.22) | 2.88 | 2,105 | 0.023 |
| Birth weight SDS | 0.59 (0.13, 1.05) | 39.13 | 2,198 | 0.012 | 2.62 (−0.43, 5.66) | 1.51 | 2,111 | 0.091 | 0.19 (−0.03, 0.41) | 1.62 | 2,105 | 0.096 |
| IPPV† | −0.53 (−0.85, −0.22) | 37.38 | 2,149 | 0.001 | −1.45 (−3.27, 0.37) | 1.33 | 2,84 | 0.118 | −0.08 (0.06, −0.22) | 0.67 | 2,81 | 0.278 |
| Infection | −1.26 (−2.17, −0.35) | 39.74 | 2,198 | 0.007 | −0.22 (−5.71, 5.28) | 0.06 | 2,111 | 0.937 | −0.02 (−0.43, 0.40) | 0.21 | 2,105 | 0.942 |
| Total WMI score | −0.17 (−0.38, 0.03) | 38.94 | 2,196 | 0.097 | −2.83 (−4.30, −1.36) | 7.31 | 2,111 | 0.006 | −0.19 (−0.30, −0.07) | 5.60 | 2,105 | 0.001 |
| Total DNGM score | −1.08 (−1.52, −0.65) | 53.78 | 2,196 | < 0.001 | −5.87 (−8.47, −3.28) | 10.11 | 2,111 | < 0.001 | −0.40 (−0.60, −0.20) | 7.80 | 2,105 | < 0.001 |
| IVH | −0.24 (−0.77, 0.30) | 35.23 | 2,194 | 0.386 | −1.42 (−4.68, 1.84) | 0.43 | 2,108 | 0.341 | −0.11 (−0.35, 0.13) | 0.72 | 2,102 | 0.376 |
| Postnatal corticosteroids | −3.22 (−4.73, −1.72) | 46.47 | 2,197 | < 0.001 | 0.61 (−11.76, 12.97) | 0.14 | 2,110 | 0.923 | 0.47 (−0.46, 1.41) | 0.67 | 2,104 | 0.316 |
| Morphine dose | −0.69 (−1.36, −0.02) | 37.56 | 2,198 | 0.043 | 1.60 (−4.35, 7.55) | 0.20 | 2,111 | 0.596 | 0.18 (−0.26, 0.61) | 0.52 | 2,105 | 0.429 |
cc – cubic centimeters; CI – confidence interval; df – degrees of freedom; DNGM – deep nuclear gray matter; GA – gestational age; IPPV – intermittent positive pressure ventilation; IVH – intraventricular hemorrhage; SDS – standard deviation score; TEA – term equivalent age; VPT – very preterm; WMI – white matter injury
*
Results of linear regression analyses for associations between perinatal factors and cerebellar volume/growth in VPT subjects, adjusted for postmenstrual age at MRI
†
Log-transformed
Bold p-values denote associations that are significant following FDR correction (pFDR < 0.05)