Table 4.
Associations between cerebellar volumes, perinatal factors and neurodevelopmental outcomes in VPT children
| TEA Volume (cc) | 7-Year Volume (cc) | Growth Z-score | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||
| Neurodevelopmental Outcome† | Coefficient (95% CI) | F | df | P-value | Coefficient (95% CI) | F | df | P-value | Coefficient (95% CI) | F | df | P-value |
| Full-scale IQ | 1.12 (0.49, 1.75) | 6.45 | 3,165 | 0.001 | 0.33 (0.16, 0.51) | 7.28 | 3,110 | < 0.001 | 4.51 (2.03, 6.99) | 8.38 | 3,104 | <0.001 |
| Performance IQ | 1.33 (0.66, 2.00) | 6.61 | 3,166 | < 0.001 | 0.43 (0.24, 0.63) | 7.10 | 4,109 | 0.005 | 5.37 (2.65, 8.08) | 7.75 | 3,104 | <0.001 |
| Verbal IQ | 0.77 (0.12, 1.43) | 4.34 | 3,167 | 0.021 | 0.18 (−0.01, 0.37) | 3.33 | 3,110 | 0.064 | 2.91 (0.25, 5.56) | 4.90 | 3,104 | 0.033 |
| Language ability | 1.01 (0.14, 1.87) | 3.05 | 3,159 | 0.023 | 0.28 (0.04, 0.53) | 3.59 | 3,107 | 0.023 | 4.30 (0.85, 7.74) | 3.31 | 3,101 | 0.015 |
| Receptive language | 1.01 (0.26, 1.77) | 3.59 | 3,158 | 0.009 | 0.46 (0.24, 0.68) | 6.52 | 3,107 | < 0.001 | 6.59 (3.56, 9.62) | 7.00 | 3,101 | <0.001 |
| Expressive language | 0.81 (−0.02, 1.64) | 2.69 | 3,159 | 0.055 | 0.23 (−0.01, 0.47) | 3.38 | 3,106 | 0.056 | 3.76 (0.41, 7.10) | 2.90 | 3,100 | 0.028 |
| Attention | 0.06 (−0.11, 0.24) | 0.86 | 3,158 | 0.483 | −0.03 (−0.08, 0.03) | 0.80 | 3,106 | 0.337 | −0.23 (−1.04, 0.59) | 0.61 | 3,100 | 0.587 |
| Working memory | 0.62 (−0.19, 1.43) | 2.32 | 3,153 | 0.134 | 0.05 (−0.20, 0.31) | 0.47 | 3,105 | 0.669 | 0.64 (−2.89, 4.17) | 1.43 | 3,99 | 0.720 |
| Motor function | 0.20 (0.03, 0.37) | 2.84 | 3,146 | 0.024 | 0.09 (0.04, 014) | 5.11 | 3,101 | < 0.001 | 1.03 (0.33, 1.73) | 3.96 | 3,95 | 0.004 |
| Balance | 0.20 (0.02, 0.38) | 3.09 | 3,147 | 0.029 | 0.10 (0.05, 0.15) | 6.75 | 3,102 | < 0.001 | 1.14 (0.40, 1.88) | 5.35 | 3,96 | 0.003 |
| Manual dexterity | 0.16 (0.01, 0.30) | 3.02 | 3,151 | 0.031 | 0.05 (0.01, 0.09) | 3.94 | 3,104 | 0.016 | 0.65 (0.07, 1.24) | 3.31 | 3,98 | 0.028 |
| Aiming and catching | 0.09 (−0.07, 0.25) | 1.61 | 3,149 | 0.276 | 0.05 (−0.002, 0.10) | 2.13 | 3,102 | 0.059 | 0.49 (−0.23, 1.21) | 2.56 | 3,96 | 0.179 |
cc – cubic centimeters; CI – confidence interval; df – degrees of freedom; IQ – intelligence quotient; TEA – term equivalent age; VPT – very preterm
†
Results of linear regression analyses for associations between cerebellar volume/growth and 7-year neurodevelopmental outcomes in VPT subjects, adjusted for sex and postmenstrual age at MRI
Bold p-values denote associations that are significant following FDR correction (pFDR < 0.05)