Table 3. Responses of the 20 Participants by Treatment and Treatment Order.
| Treatment Sequence | No. of Patients | Treatment | ||
|---|---|---|---|---|
| Placebo | Mexiletine | Reduction | ||
| Mean (SD) number cramps/d | ||||
| Placebo first | 12 | 4.7 (4.2) | 2.5 (2.8) | 2.2 (2.2) |
| Mexiletine first | 8 | 6.1 (8.1) | 4.9 (8.0) | 1.2 (2.9) |
| Mean (SD) cramp severity/d, unita | ||||
| Placebo first | 12 | 44.7 (26.7) | 32.8 (27.7) | 12.0 (18.1) |
| Mexiletine first | 8 | 43.6 (31.0) | 23.1 (16.8) | 20.5 (40.6) |
| Mean (SD) fasciculation severity/d, unita | ||||
| Placebo first | 12 | 31.7 (26.7) | 31.7 (29.0) | −0.1 (8.5) |
| Mexiletine first | 8 | 25.8 (32.7) | 32.4 (34.4) | −6.6 (23.2) |
a
Severity rated on the 100-unit visual analog scale.