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. 2018 Jul 24;32(9):2016–2020. doi: 10.1038/s41375-018-0220-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Surface markers of acutely activated HSCs. a A heatmap of 75 differentially expressed (DE) surface markers (GO:0016021, of 435 DE genes) under control (PBS) conditions and 24 h after an acute pIC stimulation. b Representative FACS plots showing the expression of CD69 (x-axis) and CD317 (Bts2, y-axis) in control conditions (PBS; top panels) and 24 h after an acute pIC stimulation (bottom panels). Plots are shown for the Lineage-negative (Lin⁻, left panels), Lineage⁻cKit⁺Sca1⁺ (LSK, middle panels), and LSKCD150⁺mCh⁺ (right panels) populations. c Quantification of the frequencies of indicated populations of CD69⁺CD317⁺ (green), CD317⁺CD69⁻ (red), and CD69⁺CD317⁻ (blue) cells. Histograms show averages and standard deviations of the control (PBS) and pIC-treated (Acute) cells; *p < 0.05, **p < 0.01