Table 2.
Meta-Analysis Results.
| Sensitivity (95% CI) | Specificity (95% CI) | PLR (95% CI) | NLR (95% CI) | DOR (95% CI) | AUC (95% CI) | |
|---|---|---|---|---|---|---|
| All Studies | 0.67 (0.64–0.70) | 0.80 (0.77–0.83) | 2.67 (1.86–3.82) | 0.46 (0.38–0.54) | 7.27 (4.39–12.05) | 0.78 |
| Sample size Large Studies (>60 patients) | 0.67 (0.64–0.71) | 0.80 (0.75–0.84) | 3.01 (1.86–4.89) | 0.39 (0.30–0.52) | 9.69 (4.36–21.55) | 0.82 |
| Sample size Small Studies (<60 patients) | 0.67 (0.61–0.74) | 0.81 (0.75–0.85) | 2.48 (1.46–4.22) | 0.53 (0.44–0.65) | 5.66 (2.91–10.99) | 0.74 |
| Detection Method (RT-PCR) | 0.61 (0.57–0.65) | 0.82 (0.77–0.87) | 2.71 (1.51–4.87) | 0.50 (0.42–0.61) | 6.28 (2.15–14.58) | 0.70 |
| Detection Method (dPCR) | 0.72 (0.68–0.76) | 0.73 (0.67–0.79) | 2.16 (1.42–3.27) | 0.45 (0.38–0.54) | 5.67 (3.22–9.98) | 0.77 |
| Detection Method (NGS) | 0.87 (0.76–0.95) | 0.89 (0.82–0.94) | 4.55 (1.00–20.83) | 0.26 (0.06–1.20) | 19.53 (1.44–264.76) | 0.88 |
CI: confidence intervals; RT-PCR: real-time PCR; dPCR: digital-PCR; NGS: next generation sequencing; PLR: positive likelihood ratio; NLR: negative likelihood ratio; DOR: diagnostic odds ratio; AUC: area under curve.