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. 2018 Sep 6;8:13315. doi: 10.1038/s41598-018-31709-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of nitroglycerin (NTG) on the vasoconstrictive effect of cerebrospinal fluid (CSF) from rats (rCSF) with subarachnoid hemorrhage (SAH). Arteriolar diameters were measured by capillary videoscopy. rCSF of SAH rats was applied on the brain surface for 120 min (B) then NTG of different concentrations was added (C–F). The vasoconstrictive effect of rCSF was reversible by application of nitroglycerin in a dose-dependent manner. The vasodilation effects were particularly obvious in the secondary and terminal arterioles (G–I).