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. 2018 Aug 31;9:1002. doi: 10.3389/fphar.2018.01002

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Copyright © 2018 Lattanzi, Rief, Schmidhammer, Negri and Spetea.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vitro binding and agonist profile of POMO at the opioid receptors. (A) Concentration-dependent inhibition by POMO and 14-OMO of [³H]DAMGO (MOR) and [³H][Ile^5,6]deltorphin II (DOR) binding using rat brain membranes, and by [³H]U69,593 (KOR) using guinea-pig brain membranes, determined in competition binding assays. (B) Concentration-dependent stimulation of [³⁵S]GTPγS binding by POMO and 14-OMO determined in the [³⁵S]GTPγS binding assays using membranes from CHO cells expressing human opioid receptors. Percentage stimulation is presented relative to the maximum simulation of reference agonists DAMGO (MOR), DPDPE (DOR), and U69,593 (KOR). Values are expressed as the mean ± SEM (n ≥ 3).