Table 1.

Binding affinities and selectivity of POMO at the opioid receptors.

	Affinity, Ki (nM)			Selectivity
	MOR	DOR	KOR	DOR/MOR	KOR/MOR
14-OMOa	0.10 ± 0.01	4.80 ± 0.22	10.2 ± 2.0	48	102
POMO	0.073 ± 0.007	0.13 ± 0.02∗∗∗	0.30 ± 0.01∗∗	1.8	4.1
Morphinea	6.55 ± 0.74	217 ± 19	113 ± 9	33	17

Competition binding assays were performed with membranes from rat brain (MOR and DOR) or guinea-pig brain (KOR). ^aData from Lattanzi et al. (2005). Values are means ± SEM of at least three experiments. ^∗∗P < 0.01 and ^∗∗∗P < 0.001 vs. 14-OMO (unpaired t-test).