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Heart rate and respiratory rate of horses prior to and following rIL-1β administration into the middle carpal joint and tibiotarsal joint. An increase in mean heart rate and respiratory rate is seen in horses receiving rIL-1β into the TTJ at 12 and 24 h, respectively, when compared to the MCJ. Error bars represent that standard error of the mean (SEM) and significance is indicated by **(P < 0.01).
