Table 2.
Specific associations between individual cytochrome P450s and metabolite production identified in this and other studies.
| C. elegans P450 enzyme | Compound | Details | Mammalian Metabolising P450 enzyme | Reference |
|---|---|---|---|---|
| CYP-35A3 & CYP-35A4 | Certain imidazole fungicides | Changes in toxicity | 17 | |
| CYP-34A9 & CYP-36A1 & CYP34A10 | Tolbutamide | RNAi knockdown - LCMS | CYP-2C8/9/19 | This study |
| CYP-13A4 | Cadmium | Changes in toxicity | 18 | |
| CYP-14A3 & CYP-34A6 | PCB52 | RNAi knockdown - GCMS | CYP1A1, 2A6, 2A8 and 2B1 | 19 |
| CYP-35A2 | Fenitrothion | Changes in toxicity | 20 | |
| CYP-35D1 | Thiabendazole | RNAi knockdown – HPLC-UV and changes in toxicity | CYP1A and CYP2B | 21, 22 |