Fig. 4. Frequent inactivating mutations of coactivators and amplification and copy number gains at gene loci of transcriptional corepressors.

TCGA data was analyzed in cBioPortal to determine frequent genetic alterations in transcriptional corepressor and coactivator enzymes (Table 1). a Inactivating mutations, bi-allelic and frameshift mutations and deletions of transcriptional coactivator enzymes in ovarian, pancreatic and liver cancers (Table 1). b Copy number (CN) gain and amplifications of corepressors was frequently observed in various tumors including ovarian cancer (OVC), pancreatic cancer (PDAC) and liver cancer (HCC) (Table 1). c Analysis of HES1 CN gains across varying degrees of differentiation grades (pathological grades) of OVC. d Analysis of CN gains of BAZ1B across varying degrees of differentiation grades PDAC. e Analysis of CN gains KDM1B gains across varying degrees of differentiation grades HCC