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. 2018 Sep 6;8:13381. doi: 10.1038/s41598-018-31249-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Impact of the small molecule (SM) treatments on microbiota diversity and relative abundance in chicken ceca. (A) Relative abundance at the phylum level. (B) Taxonomic diversity and significant differences between treatments in the cecal microbiota. In green: operational taxonomic units (OTUs) detected in the chicken ceca; in red: OTUs not detected in chicken ceca; A and B indicate whether the OTUs were significantly lower or higher, in abundance, respectively, compared to the 1% dimethyl sulfoxide (DMSO) group (P < 0.01); N and NC: not infected, not treated; D: DMSO-treated; 1, 3, 4, 5: treated with SM1, SM3, SM4, or SM5, respectively.