. 2018 Sep 6;8:13381. doi: 10.1038/s41598-018-31249-0

Table 2.

Combination effects of small molecules (SMs) and antibiotics on Salmonella enterica subsp. enterica serotype Typhimurium.

Antibiotics	AB MBC_alone (μg/ml)	SM1 (MBC_alone = 50 μM)		SM3 (MBC_alone = 25 μM)		SM4 (MBC_alone = 10 μM)		SM5 (MBC_alone = 25 μM)
Antibiotics	AB MBC_alone (μg/ml)	AB MBC_combined	SM1 MBC_combined	AB MBC_combined	SM3 MBC_combined	AB MBC_combined	SM4 MBC_combined	AB MBC_combined	SM5 MBC_combined
Ciprofloxacin	0.0625	0.001^b	40^b	0.004^b	15^b	0.004^b	7.5^b	0.004^b	20^b
		0.004^a	20^a	0.006^a	10^a	0.006	10^c
		0.006^a	5^a	0.008^a	5^a	0.006	10^c
Erythromycin	200	200^c	50	200^c	25^c	200^c	10^c	200^c	25^c
Cefotaxime	3.2	3.2^c	50	3.2^c	25^c	3.2^c	10^c	3.2^c	25^c
Nalidixic acid	16	4.8^c	40	16^c	25^c	16^c	10^c	16^c	25^c
Nalidixic acid	16	8^c	30	16^c	25^c	16^c	10^c	16^c	25^c
Cefeprime	2	0.2^a	20^a	0.4^b	20^b	0.4^c	10^c	2^c	25^c
		1.2^b	10^b	0.8^b	15^b	1.6^b	1.25^b
		1.6^b	5^b	1.2^b	2.5^b	1.6^b	1.25^b
Meropenem	0.2	0.04^b	20^b	0.08^c	20^c	0.2^c	10^c	0.2^c	25^c
		0.08^b	10^b	0.16^c	15 ^c
		0.16^b	5^b	0.16^c	15 ^c

^aSynergetic effect (FBC ≤ 0.5; reduction in MBCs superior to 75% for both antibiotic and SM). ^bAdditive effect (FBC > 0.5 and ≤ 1.0; percentage reduction in MBCs between 50% and 75% for both antibiotic and SM). ^cIndifferent (FBC > 1.0 and ≤2.0; reduction in MBCs inferior to 50% for both antibiotic and SM). Antibiotic values in μg/ml. SM values in μM. MBC: minimal bactericidal concentration; AB: antibiotic; FBC: fractional bactericidal concentration.