Table 3.
Risk (hazard ratio and 95% confidence interval) of death from 8 to 28 days by tertiles of 3 serum biomarkersa
| Protein | N | Median value (IQR) | Univariate |
Multivariate |
||
|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |||
| Day 8 | ||||||
| FGF23 | ||||||
| Tertile 1 | 35 | 1108 (1026−1239) | 1 | — | 1 | — |
| Tertile 2 | 36 | 1884 (1518−2098) | 0.82 (0.25−2.70) | 0.7491 | 0.94 (0.28−3.13) | 0.9288 |
| Tertile 3 | 36 | 6064 (3380−11,161) | 2.42 (0.92−6.37) | 0.0730 | 2.42 (0.90−6.51) | 0.0785 |
| tPA | ||||||
| Tertile 1 | 35 | 895 (842−1057) | 1 | — | 1 | — |
| Tertile 2 | 36 | 1395 (1259−1629) | 0.99 (0.28−3.44) | 0.9966 | 0.83 (0.21−3.22) | 0.7950 |
| Teritle 3 | 36 | 3183 (2473−4457) | 3.15 (1.13−8.76) | 0.0276 | 5.21 (1.67−16.21) | 0.0043 |
| IL-6 | ||||||
| Tertile 1 | 35 | 952 (822−1096) | 1 | — | 1 | — |
| Tertile 2 | 36 | 1405 (1302−1590) | 2.32 (0.60−8.98) | 0.221 | 2.64 (0.66−10.49) | 0.1671 |
| Teritle 3 | 36 | 3518 (2585−6131) | 5.50 (1.55−8.83) | 0.008 | 5.93 (1.54−22.82) | 0.0095 |
CI, confidence interval; HR, hazard ratio; IQR, interquartile range.
P < 0.05 significant: FGF23, tPA, and IL-6.
a
Fibroblast growth factor 23 (FGF23), tissue plasminogen activator (tPA), and interleukin 6 (IL-6) found elevated by slow off-rate modified aptamers scan in samples from patients with acute kidney injury who required dialysis obtained at day 8 of randomization.