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. 2018 Aug 30;9:1892. doi: 10.3389/fmicb.2018.01892

FIGURE 1.

FIGURE 1

Community profiles of saliva, BALF, and lung tissue in controls and patients. Saliva, bronchoalveolar lavage fluid (BALF) (A), and lung tissues (B) were sampled from IPF and LC patients, and saliva and BALF (A) from HS to isolate genomic DNA, amplify the V123 region of the bacterial 16S ribosomal RNA gene through high-throughput sequencing and taxonomic profiling. The abundance variation box plots as determined by read abundance for the 38 most abundant genera in IPF and LC patients are displayed and colored by taxonomic affiliation at the phylum level. Corresponding insets exhibit phylum abundance box plots. Principal component analysis (PcoA) was also calculated (C). Saliva (n = 6), BALF (n = 3), and lung tissue (n = 3) samples were available from IPF patients; saliva (n = 3) and lung tissue (n = 3) samples were available from LC patients. “Other samples” described in (C) are BALF samples from patients with collagen vascular disease-associated interstitial lung disease (n = 2) and lung tissue sample from a patient with pneumothorax (n = 1). BALF, bronchoalveolar lavage fluid; IPF, idiopathic pulmonary fibrosis; LC, lung cancer; HS, healthy subjects.