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. 2018 Aug 30;9:1892. doi: 10.3389/fmicb.2018.01892

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Copyright © 2018 D’Alessandro-Gabazza, Méndez-García, Hataji, Westergaard, Watanabe, Yasuma, Toda, Fujimoto, Nishihama, Fujiwara, Taguchi, Kobayashi, Mackie, Cann and Gabazza.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pulmonary fibrosis in transgenic (TG) mice overexpressing human transforming growth factor (TGF)-β1. CT and trichrome stain of lung tissues from WT mice (A,B) and TGF-β1 mice (C,D, arrows). H&E stain showed areas of fibrotic changes alternate with areas with less affected parenchyma (E, arrows), honeycombing-like cysts with disruption of lung parenchyma (F), and fibroblastic foci-like structures (G, arrow), and multiples areas with adenocarcinoma (H, arrows). There is increased staining of proliferating cell nuclear antigen (PCNA) in cancerous areas (I, arrows). Scale bars indicate 50 μm.