Table 1.
Baseline characteristics of REGARDS participants stratified by tertile of urinary NGAL
| Parameter | Tertile of NGAL |
P value | ||
|---|---|---|---|---|
| 1 (n = 490) | 2 (n = 491) | 3 (n = 491) | ||
| Range of NGAL, ng/ml | 0.1–26.4 | 26.5–81.4 | 81.5–5447 | |
| Age, yr | 71 (64–77) | 72 (64–78) | 70 (63–78) | 0.31 |
| Female gender | 145 (30%) | 223 (45%) | 310 (63%) | <.0001 |
| Race | ||||
| Black | 187 (38%) | 251 (51%) | 268 (55%) | <.0001 |
| White | 303 (62%) | 240 (49%) | 223 (45%) | |
| Income | 0.0021 | |||
| <$34k | 248 (59%) | 293 (68%) | 27 (6%) | |
| $35–74k | 133 (32%) | 109 (25%) | 99 (23%) | |
| $75k and above | 41 (10%) | 27 (6%) | 25 (6%) | |
| Diabetes mellitus | 246 (51%) | 230 (47%) | 241 (49%) | 0.55 |
| Hypertension | 419 (86%) | 414 (85%) | 422 (86%) | 0.92 |
| History of MI | 206 (43%) | 163 (34%) | 168 (35%) | 0.0091 |
| History of stroke | 59 (12%) | 82 (17%) | 80 (16%) | 0.075 |
| Cancer | 83 (25%) | 57 (17%) | 62 (20%) | 0.061 |
| Current alcohol use | 184 (38%) | 177 (36%) | 170 (35%) | 0.24 |
| Cigarette smoking | 0.73 | |||
| Current | 75 (15%) | 87 (18%) | 78 (16%) | |
| Past | 217 (44%) | 204 (42%) | 203 (41%) | |
| Never | 196 (40%) | 199 (41%) | 209 (43%) | |
| ASA | 271 (55%) | 256 (52%) | 239 (49%) | 0.11 |
| Lipid-lowering Rx | 239 (49%) | 213 (44%) | 213 (44%) | 0.17 |
| Systolic BP, mm Hg | 134 (123–145) | 137 (124–149) | 134 (123–148) | 0.14 |
| Diastolic BP, mm Hg | 78 (69–82) | 79 (70–83) | 78 (70–83) | 0.39 |
| BMI, kg/m2 | 29 (26–34) | 29 (25–34) | 30 (25–35) | 0.42 |
| Waist circumference, cm | 103 (91–114) | 102 (91–112) | 100 (91–111) | 0.092 |
| LDL, mg/dl | 99 (80–125) | 106 (81–127) | 104 (82–128) | 0.13 |
| HDL, mg/dl | 42 (34–52) | 44 (36–56) | 45 (37–57) | 0.0003 |
| TG, mg/dl | 136 (93–198) | 126 (92–188) | 130 (93–187) | 0.20 |
| CRP, mg/l | 3.0 (1.4–5.9) | 3.5 (1.5–8.6) | 4.9 (1.9–9.9) | <.0001 |
| ACR, mg/g | 94 (50–287) | 105 (50–482) | 142 (61–677) | <.0001 |
| eGFRcyscr | 49 (39–57) | 45 (34–55) | 44 (30–53) | <.0001 |
| eGFRcys | 43 (34–49) | 40 (29–48) | 37 (26–47) | <.0001 |
| eGFRcr | 55 (45–68) | 53 (38–66) | 51 (35–63) | <.0001 |
ACR, albumin-to-creatinine ratio; ASA, aspirin; BMI, body mass index; BP, blood pressure; CRP, C-reactive protein; eGFRcr, estimated glomerular filtration rate creatinine; eGFRcys, estimated glomerular filtration rate cystatin; eGFRcyscr, estimated glomerular filtration rate creatinine-cystatin; HDL, high-density lipoprotein; LDL, low-density lipoprotein; MI, myocardial infarction; NGAL, neutrophil gelatinase−associated lipocalin; REGARDS, REasons for Geographic and Racial Differences in Stroke; Rx, prescription; TG, triglyceride.
Data are presented as median (interquartile range) or number (percentage).