Table 3.
Main pharmacokinetic parameters of caffeine, dapsone, and chlorzoxazone in rat plasma.
| Probe drug | Pharmacokinetics | Control group | Experimental group |
|---|---|---|---|
| Caffeine | t1/2(h) | 6.76 ± 3.59 | 4.06 ± 1.99∗ |
| Cmax (mg L-1) | 9.92 ± 1.82 | 7.06 ± 1.66∗∗ | |
| AUC(0-∞) (mg L-1 h) | 77.50 ± 16.88 | 31.75 ± 5.35∗∗ | |
| MRT(0-∞) (h) | 8.05 ± 2.02 | 5.50 ± 1.59∗ | |
| CL (L h-1 kg-1) | 0.13 ± 0.03 | 0.32 ± 0.06∗∗ | |
| Dapsone | t1/2 (h) | 11.58 ± 4.72 | 8.59 ± 3.52∗ |
| Cmax (mg L-1) | 1.74 ± 0.39 | 2.01 ± 0.69 | |
| AUC(0-∞) (mg L-1 h) | 33.52 ± 8.10 | 22.83 ± 3.46∗∗ | |
| MRT(0-∞) (h) | 17.94 ± 6.60 | 12.1 ± 4.03 | |
| CL (L h-1 kg-1) | 0.31 ± 0.08 | 0.45 ± 0.06∗∗ | |
| Chlorzoxazone | t1/2 (h) | 1.29 ± 0.95 | 0.98 ± 0.63 |
| Cmax (mg L-1) | 10.90 ± 2.25 | 9.56 ± 1.50 | |
| AUC(0-∞) (mg L-1 h) | 39.74 ± 3.97 | 22.71 ± 3.91∗ | |
| MRT(0-∞) (h) | 3.42 ± 0.25 | 4.53 ± 1.58 | |
| CL (L h-1 kg-1) | 0.51 ± 0.05 | 0.90 ± 0.16∗ |
t1/2, half-life; Cmax, the peak or maximum concentration; AUC(0-∞), area under a curve extrapolated to infinity; MRT(0-∞), mean residence time; CL, the total body clearance. Values are presented as mean ± SD (n = 6).∗P < 0.05 when compared with related parameters of control group. ∗∗P < 0.01 when compared with related parameters of control group.