Table 3.
Key differentially expressed proteins identified by tandem mass tag-based proteomics analysis between patients with PD with and without depression.
| UniProt ID | Protein name (GeneName) | MW [kDa] | FC valuea | p-valueb |
|---|---|---|---|---|
| B3KY04 | Potassium channel tetramerization domain containing 12 (KCTD12) | 35.71 | 1.392 | 0.000 |
| V9HW68 | Epididymis luminal protein 214 (HEL-214) | 51.68 | 1.258 | 0.006 |
| Q68CJ9 | Cyclic AMP-responsive element-binding protein 3-like protein 3 (CREB3L3) | 49.05 | 1.357 | 0.007 |
| E9PNH1 | Neutral alpha-glucosidase AB (GANAB) | 13.15 | 1.392 | 0.009 |
| Q53HT9 | Complement component 1, r subcomponent variant | 80.19 | 1.514 | 0.012 |
| P23471 | Receptor-type tyrosine-protein phosphatase zeta (PTPRZ1) | 254.43 | 1.259 | 0.023 |
| A0A075B6R9 | Protein IGKV2D-24 (IGKV2D-24) | 13.07 | 1.506 | 0.027 |
| A0A125U0U7 | MS-C1 heavy chain variable region | 13.09 | 1.286 | 0.030 |
| Q04721 | Neurogenic locus notch homolog protein 2 (NOTCH2) | 265.23 | 1.204 | 0.030 |
| P00338 | L-lactate dehydrogenase A chain (LDHA) | 36.67 | 0.644 | 0.007 |
| U5YKD2 | MHC class I antigen (HLA-A) | 37.91 | 0.736 | 0.008 |
| Q1HP67 | Lipoprotein (LPA) | 226.37 | 0.673 | 0.008 |
| Q8NCM2 | Potassium voltage-gated channel subfamily H member 5 (KCNH5) | 111.81 | 0.822 | 0.012 |
| E7EUT5 | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) | 27.85 | 0.673 | 0.016 |
| Q5NV68 | V4-1 protein (V4-1) | 11.23 | 0.762 | 0.022 |
| I3L252 | Triokinase/FMN cyclase (TKFC) | 22.94 | 0.581 | 0.025 |
| D6RGG3 | Collagen alpha-1(XII) chain (COL12A1) | 333.00 | 0.824 | 0.043 |
a
FC value was calculated as the ratio of the average mass response (area) between the two groups (FC value = PDD/PD). Thus, FC values >1 indicate significantly higher levels in the PDD group relative to the PD group while FC values < 1 indicate significantly lower levels in the PDD group.
b
Only proteins with FC values greater than ±1.2 and p values less than 0.05 were deemed statistically significant.
PD, Parkinson's disease; MW, molecular weight; FC, fold change; PDD, Parkinson's disease related depression.