Table 4.
The plasma levels, Pearson correlation analyses with HAMD score, and ROC curves of the six proteins determined by ELISA tests in patients with PD with and without depression.
| Variable | Mean ±SEM (ng/ml) | Correlation analysis | ROC curve | ||||||
|---|---|---|---|---|---|---|---|---|---|
| PD (76) | PDD (23) | p-value | r value | p value | AUC (95%CI) | Cut-off point (ng/ml) | Sensitivity value (%) | Specificity value (%) | |
| PTPRZ1 | 1.88 ± 0.17 | 2.68 ± 0.28 | 0.000 | 0.417 | 0.000 | 0.758(0.662–0.838) | 1.564 | 86.96 | 64.47 |
| HLA-A | 0.41 ± 0.03 | 0.29 ± 0.01 | 0.013 | −0.272 | 0.006 | 0.672 (0.570–0.763) | 18.738 | 100.0 | 39.47 |
| NOTCH2 | 0.94 ± 0.19 | 1.56 ± 0.24 | 0.000 | 0.335 | 0.001 | 0.910 (0.835–0.958) | 0.857 | 95.65 | 81.58 |
| LPA | 209.56 ± 10.76 | 151.90 ± 11.14 | 0.009 | −0.354 | 0.000 | 0.681 (0.579–0.771) | 216.827 | 95.65 | 44.74 |
| LDHA | 10.83 ± 1.62 | 5.05 ± 1.07 | 0.003 | −0.251 | 0.012 | 0.707 (0.607–0.794) | 4.542 | 78.26 | 63.16 |
| GAPDH | 6.29 ± 0.33 | 4.77 ± 0.39 | 0.028 | −0.366 | 0.000 | 0.652 (0.550–0.745) | 6.203 | 86.96 | 40.79 |
HAMD, Hamilton Depression Scale; ROC, receiver operating characteristic; ELISA, enzyme-linked immune sorbent assay; PD, Parkinson's disease; SEM, standard error of the mean; ROC, receiver operator characteristics; PDD, Parkinson's disease related depression; AUC, area under the curve; CI, confidence interval; PTPRZ1, Receptor-type tyrosine-protein phosphatase zeta; HLA-A, Major histocompatibility complex class I antigen; NOTCH2, Neurogenic locus notch homolog protein 2; LPA, Lipoprotein; LDHA, L-lactate dehydrogenase A chain; GAPDH, Glyceraldehyde-3-phosphate dehydrogenase.