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Classical lissencephaly in a patient with heterozygous deletion in the LIS1 gene. (A,B) Axial T2-weighted images demonstrate the presence of posterior predominant LIS with a thick cortex. Mild ventriculomegaly is noted; (C) sagittal T1-weighted and (D) coronal T2-weighted images show normal appearances of the cerebellum and brainstem. Partial agenesis of the corpus callosum is also noted.
