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. 2018 Aug 28;9:956. doi: 10.3389/fphar.2018.00956

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Copyright © 2018 Wu, Xu, Deng, Liu, Deng, Wu, Gao and Jia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Experimental design. Animals of Control, PTX and WLT received paclitaxel/saline injection and WLT/water pediluvium during the experiment. The PIPN model was constructed by administration of paclitaxel at 8 mg/kg by intraperitoneal injection on d1, 4, 7. WLT solution was given tropically by pediiluvium twice a day for 11 consecutive days (d0-10). The behavior assay was monitored every other day (d0, 2, 4, 6, 8, 10). The rats were finally euthanized on day 10. Plasma and spinal cord samples were collected for preparation and analysis.