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. 2018 Aug 28;9:1197. doi: 10.3389/fphys.2018.01197

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Copyright © 2018 Liu, Li and Tuo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic diagram depicting the potential roles of Slc26a9 in different organs. Slc26a9 functions as a Cl^- channel in the lung and pancreases. In the stomach and kidney, Slc26a9 can function as both a Cl^- channel and Cl^-/HCO₃^- exchanger. In addition to functioning as a Cl^- channel and Cl^-/HCO₃^- exchanger, four potential roles of Slc26a9 in the duodenum have been discussed in other organs. Slc26a9 and CFTR may interact structurally and/or functionally in a positive fashion to enhance HCO₃^- secretion. Slc26a9 is a crypt enterocyte anion channel that functions indirectly with regard to transepithelial anion transport and is possibly involved in volume control/apoptosis/migration/differentiation.