Table 2.

Whole-brain seed-based functional connectivity (FC) analysis.

Region	Side	kE	Z	X	y	z	Post hoc test
SEED: DORSAL ACC
Precuneus	Left	256	4.50	−2	−46	48	IGDde+ > IGDde−> Controls
Cerebellar lobule IX	Right	129	4.12	10	−42	−40	IGDde+ > IGDde−, Controls
SEED: PREGENUAL ACC
Supplementary motor area	Right	352	5.11	32	6	64	IGDde−, Controls > IGDde+
Dorsomedial prefrontal cortex	Right	111	4.71	10	52	34	IGDde−, Controls > IGDde+
Precuneus	Right	184	4.46	16	−42	54	IGDde+, IGDde−> Controls
Posterior cingulate cortex	Left	359	4.02	−12	−22	42	IGDde+, IGDde−> Controls
Inferior frontal gyrus	Left	135	4.29	−42	2	16	IGDde−> IGDde+ > Controls
SEED: SUBGENUAL ACC
Dorsolateral prefrontal cortex	Left	254	4.34	−36	34	38	IGDde−> IGDde+, Controls
Lingual gyrus	Left	145	4.21	−18	−86	−12	IGDde−, Controls > IGDde+
Precuneus	Left	100	3.75	−8	−62	46	Controls > IGDde+
Postcentral gyrus	Left	186	3.75	−42	−12	38	IGDde−> IGDde+

Brain regions in which FC showed significant differences between groups [height threshold of uncorrected p-value < 0.001, extent threshold of contiguous k_e > 100 voxels (18)].

IGD_dep, Internet Gaming disorder subjects without comorbid depression; IGD_dep+, Internet Gaming Disorder subjects with comorbid depression; ACC, anterior cingulate cortex.