Figure 2.

PEG-MAL Matrigel Conformed Coated Islets Transplanted in the EFP Site Reverse Diabetes Long-Term in Murine Allografts without Immunosuppression

(A) Phase contrast (scale bar, 100 μm) images of naked and PEG-Matrigel conformal coated (CC (PEG MG)) islets from Lewis rats. (B and C) Blood glucose of recipient mice (B) and survival (C) of 750–1,000 islet equivalent (IEQ) naked (black; n = 13) or CC (PEG MG) (red; n = 8) islets from BALB/c mice transplanted into fully major histocompatibility complex (MHC)-mismatched chemically induced diabetic B6 mice in the epididymal fat pad using fibrin scaffolds without any immunosuppression.¹⁹⁰ (***p <.001.)