Table 2.
Inductive Hydrogel Scaffold-Mediated Delivery of Therapeutic Genes In Vivo
| Gene Delivered | Year | Scaffold Material | Delivery Strategy | Target | Ref. |
|---|---|---|---|---|---|
| Bone morphogenetic protein (BMP)-4 and parathyroid hormone | 1996 | collagen | naked DNA | bone regeneration | 188 |
| Parathyroid hormone | 1999 | collagen | naked DNA | bone regeneration | 138 |
| Hypoxia-inducible factor-1α (HIF-1α) | 2006 | fibrin | DNA/poly-L-lysine (PLL) | vessel formation | 117 |
| Vascular endothelial growth factor (VEGF) | 2009 | collagen | DNA/trimethyl chitosan (TMC) | vessel formation | 147 |
| VEGF | 2010 | collagen-chitosan | DNA/TMC | vessel formation | 153 |
| Fibroblast growth factor-2, BMP-2 | 2012 | gelatin, collagen | DNA/PEI-linoleic acid | bone regeneration | 189 |
| Platelet-derived growth factor (PDGF) | 2014 | collagen | DNA/PEI | bone regeneration | 146 |
| VEGF | 2014 | gelatin | DNA/PEI-graphene oxide | vessel formation (cardiac repair) | 125 |
| VEGF | 2014 | HA | DNA/PEI | vessel formation (wound healing) | 75 |
| VEGF | 2015 | HA | DNA/PEI | vessel formation (wound healing) | 76 |