Figure 5.

Cardiomyocyte Pathology of IV- and ICV-Treated nmd Mice Is Equally Repaired Compared to Untreated Mice

WGA-stained (A) and VVG-stained (C) cross sections of cardiomyocyte of IV- and ICV-treated males were examined at 8 weeks post-injection and compared with those of age-matched untreated nmd and healthy control males (n = 4 for each group). (A and B) The fiber area of cardiomyocytes in untreated nmd is slightly smaller than IV and healthy control but significantly decreased compared to ICV-treated nmd mice (one-way ANOVA, p < 0.05). The cardiomyocyte fiber area of IV, ICV, and healthy control are not statistically different. (C and D) The intensity of interstitial and periarterial fibrosis is significantly decreased in the cardiomyocytes of IV- and ICV-treated nmd mice compared to untreated mice (one-way ANOVA, p < 0.05). Error bars represent mean ± SEM. Scale bars, 50 μm. *p < 0.05